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ABCD1 dysfunction alters white matter microvascular perfusion

Lauer A, Da X, Hansen MB, et al. Brain. 2017;140(12):3139-3152.

Applying a vascular model to conventional dynamic susceptibility contrast magnetic resonance perfusion imaging, it ws demonstrated that lack of ABCD1 function causes increased capillary flow heterogeneity in asymptomatic hemizygotes predominantly in the white matter regions and developmental stages with the highest probability for conversion to cerebral disease.

Read the full article here doi:10.1093/brain/awx262