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Reliable estimation of microvascular flow patterns in patients with disrupted blood-brain barrier using dynamic susceptibility contrast MRI

Hansen MB, Tietze A, Kalpathy-Cramer J, et al. J Magn Reson Imaging. 2017;46(2):537-549.


To present and quantify the performance of a method to compute tissue hemodynamic parameters from dynamic susceptibility contrast (DSC) MRI data in brain tissue with possible nonintact blood-brain barrier.


We have demonstrated the robustness of the proposed Bayesian algorithm against experimental noise and demonstrated complementary value in microvascular parameters to the CBV parameter in separating tissue types in gliomas.

Get access to the full article doi:10.1002/jmri.25549