Lauer A, Da X, Hansen MB, et al. Brain. 2017;140(12):3139-3152.

Applying a vascular model to conventional dynamic susceptibility contrast magnetic resonance perfusion imaging, it ws demonstrated that lack of ABCD1 function causes increased capillary flow heterogeneity in asymptomatic hemizygotes predominantly in the white matter regions and developmental stages with the highest probability for conversion to cerebral disease.

Read the full article here doi:10.1093/brain/awx262

CLINICAL USE CASES AND TECHNICAL HIGHLIGHTS

CBCT PERFUSION IN THE ANGIO SUITE
CBCT Perfusion delivers CT-quality perfusion maps directly in the angio suite,
using standard C-arm systems. For the first time, clinicians can access
advanced tissue insights without interrupting care or delaying treatment.

CLINICAL USE CASES

Assess outcomes post-intervention: detect missed stenoses, distal occlusions, or microvascular disturbances.
Guide complementary therapies on the spot based on perfusion status.
May detect the no-reflow phenomenon — providing insight into cases where recovery may fail despite successful thrombectomy.
Potentially enables direct-to-angio workflows.

TECHNICAL HIGHLIGHTS

Full set of perfusion markers: CBF, CBV, MTT.
Advanced oxygen metabolism imaging: OEF, CMRO₂.
Reliable results with as few as 5 CBCT acquisitions (bolus injection timing protocol very important).
Integrated with Siemens and Philips systems; GE/Canon under evaluation.

CBCT Imaging

Side-by-side comparison: The left-hand side is the raw CBCT data, while the right-hand side panel is the pre-processed data.

Using CMN software in the angio suite delivers results comparable to conventional CT/MR perfusion.

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Perfusion Summit 2026

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ABCD1 dysfunction alters white matter microvascular perfusion

Lauer A, Da X, Hansen MB, et al. Brain. 2017;140(12):3139-3152.

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